Data foundation

The 340B rebate model is one of the biggest financial shifts hospitals have faced in years

Are you ready?

Incomplete or inaccurate claims can forfeit rebates and trigger compliance exposure, while missed underpayments quietly erode margin.

This creates unique operational and data integration challenges for health systems—complex and difficult to navigate alone.

Instead of upfront discounts, covered entities will need to submit for rebates after dispensing.

The HRSA 340B Rebate Model Pilot Program, launching January 1, 2026, changes how 340B discounts are applied.

Midstream transforms 340B rebates from a compliance burden into a margin opportunity

Data ingestion

We integrate directly with EHR, pharmacy, and wholesaler systems to extract and validate every claim-level field.
Ceiling price

Synchronize ceiling-price files with billing and spend systems to streamline pricing validation and Medicaid workflows.
Rebate reconciliation

Automatically reconcile submitted claims with rebate payments to identify delays and underpayments, and generate audit-ready reports.
Forecast rebate revenue

Forecast rebate revenue and model the impact of delayed payments on cash flow and budget performance, quantifying the financial impact of 340B participation.
Compliance tracking

Midstream maintains and flags complete audit trails, supporting HRSA audit readiness, and flags potential compliance risks such as duplicate discounts or GPO violations.

Protect your bottom line

Don't let new rebate requirements cost you. Catch what others miss and and capture every margin opportunity.

Quantify the impact of 340B participation

Know exactly what 340B rebates are worth to your organization.

Move from reactive scrambling to proactive control

Make confident, timely decisions backed by real-time visibility.

Midstream is filling the gaps, translating data into clarity, and transforming the tempo of decision-making itself.